| pubmed-article:8405940 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8405940 | lifeskim:mentions | umls-concept:C0006813 | lld:lifeskim |
| pubmed-article:8405940 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:8405940 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:8405940 | lifeskim:mentions | umls-concept:C1882700 | lld:lifeskim |
| pubmed-article:8405940 | lifeskim:mentions | umls-concept:C1704353 | lld:lifeskim |
| pubmed-article:8405940 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8405940 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:8405940 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:8405940 | pubmed:dateCreated | 1993-10-28 | lld:pubmed |
| pubmed-article:8405940 | pubmed:abstractText | Calcium has been reported to play an important role in regulating the intestinal electrolyte transport via Ca2+/calmodulin (CaM) and/or protein kinase C (PKC) systems. The role of Ca2+, CaM and PKC in the pathogenesis of Campylobacter jejuni-induced fluid accumulation was studied in vivo in ligated rat ileal loops. Calcium ionophore A23187 (5 microM) and PKC activator, phorbol-12-myristate-13-acetate (PMA, 100 micrograms kg-1) when injected alone induced fluid accumulation in the control loops. However, these modulators did not enhance further C. jejuni-induced fluid accumulation when injected along with C. jejuni live culture in the experimental loops. Both 1-verapamil (100 microM) and PKC antagonist, H-7 (15 micrograms/ml-1) significantly reduced C. jejuni-induced fluid accumulation (P < 0.001). The effect of CaM antagonist W-7 (60 microM) on C. jejuni-induced fluid secretion was not significant (P > 0.05). Our findings suggest that both Ca2+ and PKC appear to be the important second messengers involved in the stimulation of intestinal fluid accumulation in C. jejuni infection. | lld:pubmed |
| pubmed-article:8405940 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8405940 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8405940 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8405940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8405940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8405940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8405940 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8405940 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8405940 | pubmed:issn | 0378-1097 | lld:pubmed |
| pubmed-article:8405940 | pubmed:author | pubmed-author:KaurRR | lld:pubmed |
| pubmed-article:8405940 | pubmed:author | pubmed-author:GangulyN KNK | lld:pubmed |
| pubmed-article:8405940 | pubmed:author | pubmed-author:WaliaB NBN | lld:pubmed |
| pubmed-article:8405940 | pubmed:author | pubmed-author:KumarLL | lld:pubmed |
| pubmed-article:8405940 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8405940 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8405940 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:8405940 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8405940 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8405940 | pubmed:pagination | 327-30 | lld:pubmed |
| pubmed-article:8405940 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:meshHeading | pubmed-meshheading:8405940-... | lld:pubmed |
| pubmed-article:8405940 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8405940 | pubmed:articleTitle | Studies on the pathophysiological mechanism of Campylobacter jejuni-induced fluid secretion in rat ileum. | lld:pubmed |
| pubmed-article:8405940 | pubmed:affiliation | Department of Pediatrics, Institute of Medical Education and Research, Chandigarh, India. | lld:pubmed |
| pubmed-article:8405940 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8405940 | lld:pubmed |
