Linked Life Data

8405656

Source:http://linkedlifedata.com/resource/pubmed/id/8405656

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1993-11-4
pubmed:abstractText
1. In order to explore the mechanism of inhibition of hydroxylases involved in steroidogenesis, by gossypol, we studied the effect of this drug on adrenal cortex mitochondria, and compared it with those on kidney and heart. 2. The uncoupler effect of gossypol (collapse of delta psi and Ca2+ efflux) was found to be lower in adrenal cortex mitochondria than in kidney and heart mitochondria. 3. Gossypol produced more extensive changes on the membrane lipidic matrix (increase in the order parameter for 5-doxylstearic acid) in adrenal cortex mitochondria than in the other mitochondria studied. 4. The results described above indicate that the mechanism of inhibition of gossypol of steroidogenic adrenal enzymes could be attributed to an alteration of the lipidic matrix which, in turn, modifies protein function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0020-711X
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1149-55
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Further studies on the mechanism of action of gossypol on mitochondrial membrane.
pubmed:affiliation
Departmento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan, México, D.F.
pubmed:publicationType
Journal Article, Comparative Study