Linked Life Data

8405108

Source:http://linkedlifedata.com/resource/pubmed/id/8405108

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1993-11-9
pubmed:abstractText
Recent in vitro observations have led to the suggestion that nitric oxide (NO) plays a modulatory role in the expression of long-term potentiation (LTP). We investigated whether an NO synthesis inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME), affects the generation of LTP in anesthetized rats in vivo. Administration of L-NAME (0.1 and 1 nmol, i.c.v.) suppressed the magnitude of LTP dose dependently in the dentate gyrus of anesthetized rats. Co-injection of L-arginine, which interferes with the inhibitory action of L-NAME on NO synthesis, reversed these effects, whereas there was no reversal in rats that received co-administration with D-arginine. These results provide further support for the hypothesis that NO plays a modulatory role in the expression of synaptic potentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
238
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
395-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Inhibitory action of N omega-nitro-L-arginine methyl ester on in vivo long-term potentiation in the rat dentate gyrus.
pubmed:affiliation
First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan.
pubmed:publicationType
Journal Article