Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7-8
|
| pubmed:dateCreated |
1993-10-26
|
| pubmed:abstractText |
1. We characterized the endothelial cell-derived growth factors of SHRSP and Wistar Kyoto rats (WKY), respectively and found that platelet-derived growth factor (PDGF)-B chain related growth factor constituted a major portion of the mitogenic activity of the conditioned media of endothelial cells from both animals. There were no remarkable qualitative differences between the endothelial cell-derived growth factors of SHRSP and WKY. 2. Northern analysis revealed that the expression of PDGF-B chain was 2-4-fold enhanced in cultured aortic endothelial cells of SHRSP. This enhanced expression of PDGF-B chain, which may be induced under chronic hypertensive conditions, is suggested to contribute to the increase in endothelial cell-derived growth factors reported in this animal.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0305-1870
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
515-21
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8403533-3T3 Cells,
pubmed-meshheading:8403533-Animals,
pubmed-meshheading:8403533-Aorta,
pubmed-meshheading:8403533-Blotting, Northern,
pubmed-meshheading:8403533-Cell Division,
pubmed-meshheading:8403533-Cells, Cultured,
pubmed-meshheading:8403533-Cerebrovascular Disorders,
pubmed-meshheading:8403533-Culture Media, Conditioned,
pubmed-meshheading:8403533-Disease Susceptibility,
pubmed-meshheading:8403533-Endothelium, Vascular,
pubmed-meshheading:8403533-Hypertension,
pubmed-meshheading:8403533-Male,
pubmed-meshheading:8403533-Mice,
pubmed-meshheading:8403533-Mitogens,
pubmed-meshheading:8403533-Neutralization Tests,
pubmed-meshheading:8403533-Platelet-Derived Growth Factor,
pubmed-meshheading:8403533-Rats,
pubmed-meshheading:8403533-Rats, Inbred SHR,
pubmed-meshheading:8403533-Rats, Inbred WKY
|
| pubmed:articleTitle |
Analysis of secretion and expression of platelet-derived growth factor in cultured endothelial cells from stroke-prone spontaneously hypertensive rat.
|
| pubmed:affiliation |
Department of Neurosurgery, Kyoto University, Faculty of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|