Linked Life Data

8403465

Source:http://linkedlifedata.com/resource/pubmed/id/8403465

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-11-16
pubmed:abstractText
The density of jejunal intra-epithelial T cells expressing the gamma/delta form of the T-cell receptor is known to be increased in coeliac disease, the significance of which remains a mystery. The expression of the gamma/delta T-cell receptor in the jejunum of patients with dermatitis herpetiformis, coeliac disease, treated and untreated, and controls were studied. Expression of the gamma/delta T-cell receptor was significantly increased in patients with dermatitis hepetiformis (P < 0.0005) and in both untreated (P < 0.0005) and treated coeliac patients (P < 0.05) compared with controls. There were significant correlations between the indices of enteropathy, enterocyte height (P < 0.005) and villous height/crypt depth ratio (P < 0.0001), and expression of the gamma/delta T-cell receptor in the jejunum of all the patients. This argues against the hypothesis that gamma/delta T-cells have a fundamental role in the aetiology of gluten-sensitive enteropathy. It suggests that gamma/delta T cells may be involved in the effector arm of the mucosal immune response to cereal peptides in susceptible individuals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0307-6938
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
318-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Gamma/delta T-cell receptor expression in the jejunal epithelium of patients with dermatitis herpetiformis and coeliac disease.
pubmed:affiliation
Rayne Institute, St Thomas's Hospital, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't