Linked Life Data

8403387

Source:http://linkedlifedata.com/resource/pubmed/id/8403387

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-11-15
pubmed:abstractText
The ontogenetic pattern of kynurenine aminotransferase (KAT), the biosynthetic enzyme of the neuroprotective excitatory amino acid receptor antagonist, kynurenic acid, was examined in the rat in six brain regions and in the liver. KAT activity increased in all brain areas (but not in the liver) between 3 days and 3 months post-natum, and substantial differences were observed in the rates of the increase. For example, KAT activity in the parietal cortex increased 34-fold during the observation period, whereas enzyme activity in the cerebellum and substantia nigra increased only 3-5 fold over the same interval. Intermediate developmental changes were found in striatum, hippocampus and olfactory bulb. The differential increases in KAT activity became particularly pronounced after the second postnatal week. Since N-methyl-D-aspartate (NMDA) receptors, which are preferential targets of kynurenic acid, play an important role in brain development, the regional heterogeneity of KAT's ontogenetic profile may have a bearing on the function and dysfunction of the young central nervous system.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Regional differences in the ontogenetic pattern of kynurenine aminotransferase in the rat brain.
pubmed:affiliation
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.