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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-11-24
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pubmed:databankReference |
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pubmed:abstractText |
Repulsive guidance cues can steer neuronal growth cones during development and prevent mature axons from regenerating. We have identified a 100 kd glycoprotein in the chick brain that is a good candidate for a repulsive cue. Since it induces the collapse and paralysis of neuronal growth cones in vitro, we have named it collapsin. It is effective at concentrations of approximately 10 pM. The C-terminal half of collapsin contains a single immunoglobulin-like domain and an additional highly basic region. The N-terminal half of collapsin shares significant homology with fasciclin IV, a growth cone guidance protein in grasshopper. Recombinant collapsin causes sensory ganglion growth cones to collapse but not retinal ganglion cell growth cones. We propose that collapsin could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
217-27
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8402908-Amino Acid Sequence,
pubmed-meshheading:8402908-Animals,
pubmed-meshheading:8402908-Base Sequence,
pubmed-meshheading:8402908-Brain Chemistry,
pubmed-meshheading:8402908-Cells, Cultured,
pubmed-meshheading:8402908-Chickens,
pubmed-meshheading:8402908-Cloning, Molecular,
pubmed-meshheading:8402908-DNA, Complementary,
pubmed-meshheading:8402908-Ganglia,
pubmed-meshheading:8402908-Ganglia, Sensory,
pubmed-meshheading:8402908-Glycoproteins,
pubmed-meshheading:8402908-Molecular Sequence Data,
pubmed-meshheading:8402908-Neurons,
pubmed-meshheading:8402908-Organ Culture Techniques,
pubmed-meshheading:8402908-Organ Specificity,
pubmed-meshheading:8402908-Recombinant Proteins,
pubmed-meshheading:8402908-Retina,
pubmed-meshheading:8402908-Semaphorin-3A,
pubmed-meshheading:8402908-Sequence Analysis, DNA,
pubmed-meshheading:8402908-Sequence Homology, Amino Acid
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pubmed:year |
1993
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pubmed:articleTitle |
Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones.
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pubmed:affiliation |
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia 19104.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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