Linked Life Data

8402373

Source:http://linkedlifedata.com/resource/pubmed/id/8402373

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-11-18
pubmed:abstractText
The efficacy of the protracted infusion of 5-fluorouracil (FU) 200 mg/m2/day admixed with leucovorin (LV) 20 mg/m2/day was assessed for the treatment of advanced colorectal and breast cancer patients. Of 19 patients who underwent heavy treatment, 4 patients demonstrated partial response, 13 become stable and 2 failed to respond to therapy. The overall duration of response ranged from 1.5 to 15.8 months (median 4.5 months) and the survival ranged from 1.7 to over 21.7 months (median 8.2 months). The toxic effects, specifically mucositis, oral ulcer and acral hyperpigmentation, were mild to moderate in grade. Myelosuppression with grade I leucopenia was observed in all the patients. Catheter-related complications such as thrombosis or infection occurred in 4 patients. No death relating to therapy was reported in this study. Continuous intravenous infusion chemotherapy with an admixture of LV and FU is not associated with severe toxic effects when treatment is closely monitored and appropriately administered. This treatment regimen may have some significant benefit in advanced colorectal and breast cancer patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0578-1337
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-91
pubmed:dateRevised
2006-4-24
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Continuous intravenous infusion of leucovorin and 5-fluorouracil for the treatment of advanced colorectal and breast cancers.
pubmed:affiliation
Department of Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.
pubmed:publicationType
Journal Article