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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1993-10-28
|
| pubmed:abstractText |
Oophorectomy (OOX) has been known to increase bone turnover, but its precise mechanism is not fully understood. In order to further investigate the mechanism, we determined insulinlike growth factor I (IGF-I) concentrations in serum and bone tissue and interleukin 1 (IL-1) release from spleen macrophages in oophorectomized rats because it has been demonstrated that IGF-I stimulates bone formation and IL-1 stimulates bone resorption. Female 8-week-old Wistar rats were divided into four groups: (1) control, (2) OOX, (3) OOX given estradiol, and (4) control given estradiol. Ten micrograms/kg of 17 beta-estradiol was given daily by subcutaneous injection. After 5 weeks of treatment, IGF-I concentrations in the extract from right femur and in serum were determined by specific radioimmunoassay. IL-1 activity released from lipopolysaccharide (LPS)-stimulated spleen macrophages was determined by bioassay. IGF-I contents in the femur and IGF-I concentrations in serum in oophorectomized rats were significantly higher than those in control rats. Treatment by estradiol inhibited the increase in IGF-I concentrations both in femur and in serum. IL-1 release from LPS-stimulated spleen macrophages in oophorectomized rats was increased, and treatment by estradiol also inhibited the stimulated IL-1 release. The ash weights and the calcium contents of left femur in oophorectomized rats were lower than those in control rats. These results suggest that both IGF-I and IL-1 may be involved in the mechanism of the regulation of bone turnover in oophorectomized rats.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0171-967X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
111-6
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8402318-Animals,
pubmed-meshheading:8402318-Body Weight,
pubmed-meshheading:8402318-Bone Development,
pubmed-meshheading:8402318-Bone and Bones,
pubmed-meshheading:8402318-Calcium,
pubmed-meshheading:8402318-Cells, Cultured,
pubmed-meshheading:8402318-Estradiol,
pubmed-meshheading:8402318-Estrogen Replacement Therapy,
pubmed-meshheading:8402318-Estrogens,
pubmed-meshheading:8402318-Female,
pubmed-meshheading:8402318-Femur,
pubmed-meshheading:8402318-Injections, Subcutaneous,
pubmed-meshheading:8402318-Insulin-Like Growth Factor I,
pubmed-meshheading:8402318-Interleukin-1,
pubmed-meshheading:8402318-Macrophages,
pubmed-meshheading:8402318-Osteocalcin,
pubmed-meshheading:8402318-Ovariectomy,
pubmed-meshheading:8402318-Radioimmunoassay,
pubmed-meshheading:8402318-Rats,
pubmed-meshheading:8402318-Rats, Wistar,
pubmed-meshheading:8402318-Spleen
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Effects of estrogen replacement on insulin-like growth factor I concentrations in serum and bone tissue and on interleukin 1 secretion from spleen macrophages in oophorectomized rats.
|
| pubmed:affiliation |
Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|