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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1993-11-16
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pubmed:abstractText |
The purpose of this study was to synthesize new bifunctional linker-chelating agents for the modification of the in vivo distribution of 111In-labeled antibodies. A general simple synthetic method of preparing cyclohexyl EDTA (CDTA) derivatives containing a linker/spacer group is described. Linkers prepared included a diester, a six carbon aliphatic chain, two thioethers and a disulfide group. The CDTA-linker compounds were coupled to F(Ab')2 fragments of anti-carcinoembryonic antigen monoclonal antibody and labeled with 111In with good retention of immunoreactivity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0969-8051
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
755-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8401376-Animals,
pubmed-meshheading:8401376-Carcinoembryonic Antigen,
pubmed-meshheading:8401376-Chelating Agents,
pubmed-meshheading:8401376-Chromatography, High Pressure Liquid,
pubmed-meshheading:8401376-Cross-Linking Reagents,
pubmed-meshheading:8401376-Drug Stability,
pubmed-meshheading:8401376-Edetic Acid,
pubmed-meshheading:8401376-Immunoglobulin Fragments,
pubmed-meshheading:8401376-Indium Radioisotopes,
pubmed-meshheading:8401376-Isotope Labeling,
pubmed-meshheading:8401376-Mice,
pubmed-meshheading:8401376-Reproducibility of Results
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pubmed:year |
1993
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pubmed:articleTitle |
Introduction of five potentially metabolizable linking groups between 111In-cyclohexyl EDTA derivatives and F(ab')2 fragments of anti-carcinoembryonic antigen antibody--I. A new reproducible synthetic method.
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pubmed:affiliation |
INSERM Unit 211, Nantes, France.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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