Linked Life Data

8400423

Source:http://linkedlifedata.com/resource/pubmed/id/8400423

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-11-1
pubmed:abstractText
During blastocyst implantation and placentation in common laboratory rodents, trophoblast cells come into increasingly more intimate associations with the endometrium and, eventually, are in contact with maternal blood. Uterine cell death is one mechanism for removing uterine tissues, primarily epithelial cells, and decidual cells that intervene between trophoblast cells and maternal blood. Mechanisms of cell death and the signals that initiate and regulate it are not well understood. According to current theories, cell death is either gene-directed or the result of traumatic injury, and classification of cell death is based on ultrastructural and biochemical criteria that hypothetically reflect underlying molecular mechanisms. Although the term apoptosis is extensively used to describe all aspects of gene-directed cell death and the term necrosis to describe traumatic death, ultrastructural studies indicate that there are morphological variations of the established criteria, and these could reflect variations of underlying mechanisms. Recent light and electron microscopic work has shown that timing and ultrastructure of uterine cell death at the gestation site varies with region suggesting that initiation and control of cell death is complicated and that more than one mechanism of cell death may be operative. Current information indicates that uterine cell death is most likely part of an intrinsic response of the endometrium to the conceptus, and other than acting as a stimulus to elicit the uterine response, the conceptus probably plays only a minor role in regulating the death of endometrial cells in these species.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1059-910X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-45
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Uterine cell death during implantation and early placentation.
pubmed:affiliation
Department of Cell Biology and Human Anatomy, University of California, Davis 95616.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review