| pubmed-article:8399909 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8399909 | lifeskim:mentions | umls-concept:C0024671 | lld:lifeskim |
| pubmed-article:8399909 | lifeskim:mentions | umls-concept:C0026944 | lld:lifeskim |
| pubmed-article:8399909 | lifeskim:mentions | umls-concept:C0317824 | lld:lifeskim |
| pubmed-article:8399909 | lifeskim:mentions | umls-concept:C0206527 | lld:lifeskim |
| pubmed-article:8399909 | lifeskim:mentions | umls-concept:C1963758 | lld:lifeskim |
| pubmed-article:8399909 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8399909 | pubmed:dateCreated | 1993-11-9 | lld:pubmed |
| pubmed-article:8399909 | pubmed:abstractText | Mycoplasma arthritidis produces a potent superantigen (MAM) that activates specific murine and human T lymphocytes to proliferate and secrete lymphokines. We show here that MAM also influences both T- and B-cell functions in vivo. Lymphocytes from mice injected with MAM exhibit a suppression of proliferative responses to MAM in vitro but only a partial suppression of responses to other mitogens. This T-cell anergy not only decreased contact sensitivity to dinitrofluorobenzene but also prolonged survival of skin transplants. In contrast, B-cell reactivity is increased following in vivo injection of MAM, as evidenced by enhanced antibody responses to sheep red blood cells and ovalbumin. Also, there is a marked decrease in the ability of splenocytes from MAM-injected mice to produce interleukin-2 (IL-2) but a marked increase in their ability to produce IL-4 and IL-6. The combined results suggest that MAM induces a lymphokine profile that favors activation of B-cell functions, with a resulting potential for triggering of autoimmune disease. | lld:pubmed |
| pubmed-article:8399909 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8399909 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8399909 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8399909 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8399909 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8399909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8399909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8399909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8399909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8399909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8399909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8399909 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8399909 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8399909 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8399909 | pubmed:issn | 1058-4838 | lld:pubmed |
| pubmed-article:8399909 | pubmed:author | pubmed-author:AraneoB ABA | lld:pubmed |
| pubmed-article:8399909 | pubmed:author | pubmed-author:ColeB CBC | lld:pubmed |
| pubmed-article:8399909 | pubmed:author | pubmed-author:AhmedEE | lld:pubmed |
| pubmed-article:8399909 | pubmed:author | pubmed-author:AtkinC LCL | lld:pubmed |
| pubmed-article:8399909 | pubmed:author | pubmed-author:ShelbyJJ | lld:pubmed |
| pubmed-article:8399909 | pubmed:author | pubmed-author:WeiSS | lld:pubmed |
| pubmed-article:8399909 | pubmed:author | pubmed-author:McCallSS | lld:pubmed |
| pubmed-article:8399909 | pubmed:author | pubmed-author:KamerathCC | lld:pubmed |
| pubmed-article:8399909 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8399909 | pubmed:volume | 17 Suppl 1 | lld:pubmed |
| pubmed-article:8399909 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8399909 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8399909 | pubmed:pagination | S163-9 | lld:pubmed |
| pubmed-article:8399909 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8399909 | pubmed:meshHeading | pubmed-meshheading:8399909-... | lld:pubmed |
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| pubmed-article:8399909 | pubmed:meshHeading | pubmed-meshheading:8399909-... | lld:pubmed |
| pubmed-article:8399909 | pubmed:meshHeading | pubmed-meshheading:8399909-... | lld:pubmed |
| pubmed-article:8399909 | pubmed:meshHeading | pubmed-meshheading:8399909-... | lld:pubmed |
| pubmed-article:8399909 | pubmed:meshHeading | pubmed-meshheading:8399909-... | lld:pubmed |
| pubmed-article:8399909 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8399909 | pubmed:articleTitle | Immunomodulation in vivo by the Mycoplasma arthritidis superantigen, MAM. | lld:pubmed |
| pubmed-article:8399909 | pubmed:affiliation | Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132. | lld:pubmed |
| pubmed-article:8399909 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8399909 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8399909 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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