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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1993-11-9
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pubmed:abstractText |
Mycoplasma arthritidis produces a potent superantigen (MAM) that activates specific murine and human T lymphocytes to proliferate and secrete lymphokines. We show here that MAM also influences both T- and B-cell functions in vivo. Lymphocytes from mice injected with MAM exhibit a suppression of proliferative responses to MAM in vitro but only a partial suppression of responses to other mitogens. This T-cell anergy not only decreased contact sensitivity to dinitrofluorobenzene but also prolonged survival of skin transplants. In contrast, B-cell reactivity is increased following in vivo injection of MAM, as evidenced by enhanced antibody responses to sheep red blood cells and ovalbumin. Also, there is a marked decrease in the ability of splenocytes from MAM-injected mice to produce interleukin-2 (IL-2) but a marked increase in their ability to produce IL-4 and IL-6. The combined results suggest that MAM induces a lymphokine profile that favors activation of B-cell functions, with a resulting potential for triggering of autoimmune disease.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogens,
http://linkedlifedata.com/resource/pubmed/chemical/Mycoplasma arthritidis mitogen,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Superantigens
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1058-4838
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
17 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S163-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8399909-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8399909-Animals,
pubmed-meshheading:8399909-Antigens,
pubmed-meshheading:8399909-Antigens, Bacterial,
pubmed-meshheading:8399909-B-Lymphocytes,
pubmed-meshheading:8399909-Humans,
pubmed-meshheading:8399909-Lymphokines,
pubmed-meshheading:8399909-Mice,
pubmed-meshheading:8399909-Mice, Inbred BALB C,
pubmed-meshheading:8399909-Mice, Inbred C3H,
pubmed-meshheading:8399909-Mice, Inbred CBA,
pubmed-meshheading:8399909-Mitogens,
pubmed-meshheading:8399909-Mycoplasma,
pubmed-meshheading:8399909-Proteins,
pubmed-meshheading:8399909-Superantigens,
pubmed-meshheading:8399909-T-Lymphocytes
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pubmed:year |
1993
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pubmed:articleTitle |
Immunomodulation in vivo by the Mycoplasma arthritidis superantigen, MAM.
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pubmed:affiliation |
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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