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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1993-11-1
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pubmed:abstractText |
One line of thought in organ transplantation feels that immunosuppressive drugs can lead to tolerance induction by allowing a previously unrecognized common mechanism of cell migration and microchimerism to occur, persist, and in some cases, become drug independent. It has been recognized that there is a spectrum of susceptibility of different organs to cellular rejection and that the variable ability of these organs to induce donor-specific nonreactivity reflects their comparative content of migratory leukocytes. Here, Thomas Starzl and colleagues discuss how many of the enigmas of transplantation immunology can be explained by this chimerism.
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pubmed:grant | |
pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
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pubmed:issn |
0167-5699
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
326-32
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:8397774-Animals,
pubmed-meshheading:8397774-Cell Movement,
pubmed-meshheading:8397774-Chimera,
pubmed-meshheading:8397774-Graft Rejection,
pubmed-meshheading:8397774-Humans,
pubmed-meshheading:8397774-Immune Tolerance,
pubmed-meshheading:8397774-Immunosuppressive Agents,
pubmed-meshheading:8397774-Lymphocytes,
pubmed-meshheading:8397774-Organ Transplantation,
pubmed-meshheading:8397774-Tissue Donors
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pubmed:year |
1993
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pubmed:articleTitle |
Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation.
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pubmed:affiliation |
Dept of Surgery, University of Pittsburgh Health Science Center, PA 15213.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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