|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0013935,
umls-concept:C0019564,
umls-concept:C0027882,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0439799,
umls-concept:C0549178,
umls-concept:C0596019,
umls-concept:C1817652,
umls-concept:C1879547
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1993-10-21
|
|
pubmed:abstractText |
Throughout the adult vertebrate central nervous system (CNS) gamma-aminobutyric acid (GABA) mediates transient Cl- conductances commonly identified as fast, Cl(-)-dependent inhibitory synaptic signals [Prog. Neurobiol., 36 (1991) 35-92]. In the rat hippocampus Cl(-)-dependent excitatory transients mediated by GABA emerge during the first postnatal week superimposed on a steady-state baseline that is also Cl(-)- and GABA-dependent [Int. J. Dev. Neurosci., 8 (1990) 481-490]. Here we report that many embryonic rat hippocampal neurons cultured for hours to days exhibit random fluctuations in Cl- channel activity that are mediated by continuous secretion of GABA in the absence of transients. Thus, GABA is broadcast tonically before it is released transiently.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0304-3940
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
11
|
|
pubmed:volume |
155
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
199-203
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:8397353-Action Potentials,
pubmed-meshheading:8397353-Animals,
pubmed-meshheading:8397353-Animals, Newborn,
pubmed-meshheading:8397353-Cell Communication,
pubmed-meshheading:8397353-Cells, Cultured,
pubmed-meshheading:8397353-Chloride Channels,
pubmed-meshheading:8397353-Chlorides,
pubmed-meshheading:8397353-Hippocampus,
pubmed-meshheading:8397353-Ion Channel Gating,
pubmed-meshheading:8397353-Membrane Proteins,
pubmed-meshheading:8397353-Neurons,
pubmed-meshheading:8397353-Rats,
pubmed-meshheading:8397353-Receptors, GABA-A,
pubmed-meshheading:8397353-Synaptic Transmission,
pubmed-meshheading:8397353-gamma-Aminobutyric Acid
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Cl- channels are randomly activated by continuous GABA secretion in cultured embryonic rat hippocampal neurons.
|
|
pubmed:affiliation |
Laboratory of Neurophysiology, NINDS, National Institutes of Health, Bethesda, MD 20892.
|
|
pubmed:publicationType |
Journal Article
|
