Linked Life Data

8397126

Source:http://linkedlifedata.com/resource/pubmed/id/8397126

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1993-10-21
pubmed:abstractText
L-Fucose is a monosaccharide that occurs in low concentrations in normal serum but has been shown to be increased in diabetic individuals. In cultured mammalian cells, L-fucose is a potent competitive inhibitor of myo-inositol transport. Abnormal myo-inositol metabolism has been proposed to be a factor in the development of diabetic complications. To test the hypothesis that myo-inositol deficiency may be responsible for the electrophysiological and biological defects in diabetic neuropathy, rats were fed a diet containing 10 or 20% L-fucose for a period of 6 wk. After 3 wk, the L-fucose diets in two groups of rats were supplemented with 1% myo-inositol. At the end of the study protocol, motor nerve conduction velocity, sciatic nerve tissue Na(+)-K(+)-ATPase activity, and myo-inositol content were determined. These results were compared with those of STZ-induced diabetic rats fed either a normal diet or a diet containing 1% myo-inositol or with those given 450 mg/kg body wt of sorbinil. Serum L-fucose levels were significantly increased in rats fed a diet containing 10 or 20% L-fucose. In comparison, the serum L-fucose levels in the diabetic rats were increased to a lesser extent. Motor nerve conduction velocity was significantly slower in rats fed a 10 or 20% L-fucose diet. Sciatic nerve composite and ouabain-sensitive Na(+)-K(+)-ATPase activity and myo-inositol content was also significantly decreased. Supplementation of 1% myo-inositol to the L-fucose-containing diet restored nerve myo-inositol levels and significantly improved Na(+)-K(+)-ATPase activity and motor nerve conduction velocity.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1401-6
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:8397126-Animals, pubmed-meshheading:8397126-Biological Transport, pubmed-meshheading:8397126-Cells, Cultured, pubmed-meshheading:8397126-Diabetes Mellitus, Experimental, pubmed-meshheading:8397126-Diabetic Neuropathies, pubmed-meshheading:8397126-Dietary Carbohydrates, pubmed-meshheading:8397126-Dose-Response Relationship, Drug, pubmed-meshheading:8397126-Fucose, pubmed-meshheading:8397126-Imidazoles, pubmed-meshheading:8397126-Imidazolidines, pubmed-meshheading:8397126-Inositol, pubmed-meshheading:8397126-Male, pubmed-meshheading:8397126-Motor Neurons, pubmed-meshheading:8397126-Neural Conduction, pubmed-meshheading:8397126-Ouabain, pubmed-meshheading:8397126-Rats, pubmed-meshheading:8397126-Rats, Sprague-Dawley, pubmed-meshheading:8397126-Sciatic Nerve, pubmed-meshheading:8397126-Sodium-Potassium-Exchanging ATPase, pubmed-meshheading:8397126-Streptozocin, pubmed-meshheading:8397126-Time Factors
pubmed:year
1993
pubmed:articleTitle
Reduced motor nerve conduction velocity and Na(+)-K(+)-ATPase activity in rats maintained on L-fucose diet. Reversal by myo-inositol supplementation.
pubmed:affiliation
Department of Internal Medicine, University of Iowa, Iowa City.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't