Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1993-10-18
|
pubmed:databankReference | |
pubmed:abstractText |
We have isolated a cDNA, from the chicken, that encodes a fourth type of gamma subunit of the vertebrate brain GABAA receptor. The mature polypeptide (which we name gamma 4) displays 67%, 69% and 70% identity, respectively, to the rat gamma 1, gamma 2 and gamma 3 subunits. In the developing chicken brain, the gamma 4-subunit mRNA is first detected at embryonic day 13; the transcript level then increases progressively during embryogenesis. In situ hybridization reveals that the gamma 4-subunit mRNA is abundant in several brain regions, including the ectostriatum, nucleus rotundus and hyperstriatum ventrale, which are involved in visual processing and learning.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0014-5793
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
4
|
pubmed:volume |
331
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
211-6
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8397108-Amino Acid Sequence,
pubmed-meshheading:8397108-Animals,
pubmed-meshheading:8397108-Base Sequence,
pubmed-meshheading:8397108-Brain,
pubmed-meshheading:8397108-Chick Embryo,
pubmed-meshheading:8397108-Cloning, Molecular,
pubmed-meshheading:8397108-Gene Expression,
pubmed-meshheading:8397108-Genes,
pubmed-meshheading:8397108-In Situ Hybridization,
pubmed-meshheading:8397108-Molecular Sequence Data,
pubmed-meshheading:8397108-Oligodeoxyribonucleotides,
pubmed-meshheading:8397108-RNA, Messenger,
pubmed-meshheading:8397108-Rats,
pubmed-meshheading:8397108-Receptors, GABA-A,
pubmed-meshheading:8397108-Sequence Alignment
|
pubmed:year |
1993
|
pubmed:articleTitle |
Molecular cloning reveals the existence of a fourth gamma subunit of the vertebrate brain GABAA receptor.
|
pubmed:affiliation |
Institut für Zellbiochemie und klinische Neurobiologie, Universitäts-Krankenhaus Eppendorf, Universität Hamburg, Germany.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|