| pubmed-article:8396819 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8396819 | lifeskim:mentions | umls-concept:C0014644 | lld:lifeskim |
| pubmed-article:8396819 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8396819 | lifeskim:mentions | umls-concept:C1199284 | lld:lifeskim |
| pubmed-article:8396819 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8396819 | lifeskim:mentions | umls-concept:C0011522 | lld:lifeskim |
| pubmed-article:8396819 | lifeskim:mentions | umls-concept:C0012892 | lld:lifeskim |
| pubmed-article:8396819 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8396819 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:8396819 | lifeskim:mentions | umls-concept:C1704222 | lld:lifeskim |
| pubmed-article:8396819 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8396819 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8396819 | lifeskim:mentions | umls-concept:C1204024 | lld:lifeskim |
| pubmed-article:8396819 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8396819 | pubmed:dateCreated | 1993-10-14 | lld:pubmed |
| pubmed-article:8396819 | pubmed:abstractText | The replication of Epstein-Barr virus (EBV) and the expression of EBV early proteins were studied in the Burkitt's lymphoma cell line Akata stimulated with anti-human immunoglobulin G antibody (anti-IgG). Akata cells contained approximately 20 copies of EBV genome per cell as covalently closed, circular DNA. EBV DNA replication was observed at 6 hr and reached a maximal level at 24 hr after treatment with anti-IgG. Virion DNA was found in the culture medium at 12 hr. The kinetics of expression of BMRF1 gene product (early antigen diffuse component; EA-D) paralleled that of EBV deoxyribonuclease (DNase) and of DNA polymerase. Immunoblotting analysis showed that three polypeptides with molecular masses of 54, 52, and 49 kilodaltons (kDa) were recognized as EA-D components. The EBV DNase polypeptide was detected by immunoblotting at 53 kDa. The anti-EBV DNA polymerase antibody recognized 120- and 54-kDa polypeptides in the Akata cells. Immunoprecipitation followed by immunoblotting showed that EA-D and EBV DNase polypeptides were coimmunoprecipitated with anti-EBV DNase antibody and with anti-EA-D monoclonal antibody. These findings indicate that EA-D forms a complex with EBV DNase polypeptide. The molecules of EA-D, EBV DNase, and DNA polymerase appear to be closely associated together on the EBV replication. | lld:pubmed |
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| pubmed-article:8396819 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8396819 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8396819 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8396819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8396819 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8396819 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8396819 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8396819 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:8396819 | pubmed:author | pubmed-author:SairenjiTT | lld:pubmed |
| pubmed-article:8396819 | pubmed:author | pubmed-author:DaibataMM | lld:pubmed |
| pubmed-article:8396819 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8396819 | pubmed:volume | 196 | lld:pubmed |
| pubmed-article:8396819 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8396819 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8396819 | pubmed:pagination | 900-4 | lld:pubmed |
| pubmed-article:8396819 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8396819 | pubmed:meshHeading | pubmed-meshheading:8396819-... | lld:pubmed |
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| pubmed-article:8396819 | pubmed:meshHeading | pubmed-meshheading:8396819-... | lld:pubmed |
| pubmed-article:8396819 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8396819 | pubmed:articleTitle | Epstein-Barr virus (EBV) replication and expressions of EA-D (BMRF1 gene product), virus-specific deoxyribonuclease, and DNA polymerase in EBV-activated Akata cells. | lld:pubmed |
| pubmed-article:8396819 | pubmed:affiliation | Department of Pharmacology, University of Massachusetts Medical School, Worcester 01655. | lld:pubmed |
| pubmed-article:8396819 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8396819 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8396819 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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