Linked Life Data

8395949

Source:http://linkedlifedata.com/resource/pubmed/id/8395949

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-10-4
pubmed:abstractText
Although adenosine has been considered to depress release of neurotransmitter in central synapses, evidence for this notion is circumstantial. To obtain more direct and quantitative evidence, the suppressing action of adenosine on transmission through the mossy fiber synapse was examined by a quantal analysis in thin transverse sections of the guinea pig hippocampus. Adenosine suppressed excitatory postsynaptic potentials (EPSPs) induced in CA3 neurons by activation of single mossy fibers to 57 +/- 19% at 10 microM (6 neurons). The input resistance of the postsynaptic neurons was reduced to 84 +/- 5%. The suppression of the unitary EPSPs was accompanied by a reduction of the mean quantal content (m) to 51 +/- 13% with no significant decrease in mean quantal amplitude (q). These findings indicate that adenosine at 10 microM suppresses transmission through mossy fiber synapses mainly by depressing release of transmitter. This study provides direct evidence for the presynaptic action of adenosine on central synapses for the first time.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1050-9631
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Quantal analysis of modulating action of adenosine on the mossy fiber synapse in hippocampal slices.
pubmed:affiliation
Department of Physiology, Faculty of Medicine, Kanazawa University, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't