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rdf:type |
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lifeskim:mentions |
umls-concept:C0009017,
umls-concept:C0017262,
umls-concept:C0018956,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0185117,
umls-concept:C0216680,
umls-concept:C0453920,
umls-concept:C1335675,
umls-concept:C1539965,
umls-concept:C1705742,
umls-concept:C1880022,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
1993-9-28
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pubmed:databankReference |
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pubmed:abstractText |
To identify receptor tyrosine kinases (RTKs) critical to early hematopoiesis, we performed polymerase chain reaction-based cloning from yolk sac and highly enriched bone marrow hematopoietic stem cells (HSCs). Characterization of two novel genes of their full-length cDNA sequences revealed that they were mouse homologues of the endothelial cell RTK genes, TIE and TEK. They shared a unique structural property of coexistent immunoglobulin-like domain, epidermal growth factor-like repeats, and fibronectin type III repeats in their extracellular domains. Both genes were expressed in a similar fashion in adult tissues and primitive hematopoietic cells, predominantly in the bone marrow HSCs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, TIE
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
195
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8395828-Amino Acid Sequence,
pubmed-meshheading:8395828-Animals,
pubmed-meshheading:8395828-Base Sequence,
pubmed-meshheading:8395828-Blotting, Northern,
pubmed-meshheading:8395828-Bone Marrow,
pubmed-meshheading:8395828-Cell Line,
pubmed-meshheading:8395828-Cloning, Molecular,
pubmed-meshheading:8395828-Conserved Sequence,
pubmed-meshheading:8395828-Epidermal Growth Factor,
pubmed-meshheading:8395828-Fetus,
pubmed-meshheading:8395828-Gene Library,
pubmed-meshheading:8395828-Hematopoietic Stem Cells,
pubmed-meshheading:8395828-Humans,
pubmed-meshheading:8395828-Leukemia, Experimental,
pubmed-meshheading:8395828-Liver,
pubmed-meshheading:8395828-Mice,
pubmed-meshheading:8395828-Mice, Inbred BALB C,
pubmed-meshheading:8395828-Molecular Sequence Data,
pubmed-meshheading:8395828-Oligodeoxyribonucleotides,
pubmed-meshheading:8395828-Oligonucleotides, Antisense,
pubmed-meshheading:8395828-Protein Biosynthesis,
pubmed-meshheading:8395828-Protein-Tyrosine Kinases,
pubmed-meshheading:8395828-Proteins,
pubmed-meshheading:8395828-RNA, Messenger,
pubmed-meshheading:8395828-Receptors, Cell Surface,
pubmed-meshheading:8395828-Receptors, TIE,
pubmed-meshheading:8395828-Sequence Homology, Amino Acid,
pubmed-meshheading:8395828-Yolk Sac
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pubmed:year |
1993
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pubmed:articleTitle |
Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells.
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pubmed:affiliation |
Department of Cell Differentiation, Kumamoto University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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