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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1 Pt 1
|
| pubmed:dateCreated |
1993-8-26
|
| pubmed:abstractText |
The late-gestation ovine fetus (> 130 days, 0.90 gestation, full term 145 days) is capable of increased pituitary-adrenal activity following a variety of stressors. To examine the relationship between plasma immunoreactive adrenocorticotropic hormone (iACTH) and bioactive ACTH-like activity (bACTH), late-gestation fetuses were studied under nonstress (group I, chronically catheterized), "mild" stress (group II, acutely exteriorized), or marked stress (group III, acutely exteriorized and hemorrhaged 30% of blood volume). Plasma iACTH was determined by standard radioimmunoassay. Plasma bACTH was determined by a bioassay that utilized dispersed rat adrenal cells. Plasma iACTH was lower in group I than in groups II or III (78.4 +/- 16.3 vs. 320 +/- 116 and 622 +/- 144 pg/ml, respectively, mean +/- SE, P < 0.05 group I vs. III). Plasma bACTH was significantly lower in groups I and II than in group III (13.8 +/- 2.7 and 52 +/- 22 vs. 601 +/- 106 pg/ml, respectively, P < 0.05). The ratio of bACTH to iACTH was low in groups I and II but elevated in group III (0.188 +/- 0.028 and 0.091 +/- 0.07 vs. 0.996 +/- 0.122, P < 0.05). We conclude that the amount of bACTH compared with iACTH in the late-gestation fetus is low under nonstress states or mild stress and that bACTH increases disproportionately compared with iACTH after marked stress. This suggests that a change in ACTH processing and/or secretion is associated with stimulus intensity in the late-gestation ovine fetus.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0002-9513
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
265
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
E68-73
|
| pubmed:dateRevised |
2010-10-5
|
| pubmed:meshHeading |
pubmed-meshheading:8393292-Adrenocorticotropic Hormone,
pubmed-meshheading:8393292-Animals,
pubmed-meshheading:8393292-Biological Assay,
pubmed-meshheading:8393292-Female,
pubmed-meshheading:8393292-Fetal Diseases,
pubmed-meshheading:8393292-Gestational Age,
pubmed-meshheading:8393292-Hemorrhage,
pubmed-meshheading:8393292-Pregnancy,
pubmed-meshheading:8393292-Radioimmunoassay,
pubmed-meshheading:8393292-Sheep,
pubmed-meshheading:8393292-Stress, Physiological
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Bioactive-to-immunoreactive ACTH activity changes with severity of stress in late-gestation ovine fetus.
|
| pubmed:affiliation |
Department of Obstetrics and Gynecology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1066.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|