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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
14
|
| pubmed:dateCreated |
1993-8-26
|
| pubmed:abstractText |
A series of compounds has been synthesized and demonstrated to be antagonists of V1 receptors both in vitro and in vivo. These compounds are structurally related to the 1-(4-piperidyl)-2(1H)-quinolinones, including OPC-21268, an orally bioavailable AVP V1 antagonist with high V1 specificity. It has been found that the introduction of an acetamide group on the terminal alkoxy chain of 41-44 leads to an increase in oral activity. Certain of these compounds may have efficacy in the study of AVP V1 receptors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
9
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2011-7
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8393113-Administration, Oral,
pubmed-meshheading:8393113-Animals,
pubmed-meshheading:8393113-Binding Sites,
pubmed-meshheading:8393113-Kidney,
pubmed-meshheading:8393113-Liver,
pubmed-meshheading:8393113-Piperidines,
pubmed-meshheading:8393113-Quinolones,
pubmed-meshheading:8393113-Rats,
pubmed-meshheading:8393113-Receptors, Vasopressin,
pubmed-meshheading:8393113-Structure-Activity Relationship
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Orally active, nonpeptide vasopressin V1 antagonists. A novel series of 1-(1-substituted 4-piperidyl)-3,4-dihdyro-2(1H)-quinolinone.
|
| pubmed:affiliation |
Second Institute of New Drug Research, Otsuka Pharmaceutical Co., Tokushima, Japan.
|
| pubmed:publicationType |
Journal Article
|