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pubmed-article:8392941pubmed:abstractTextThe pharmacology of (DL)-4-carboxy-3-hydroxyphenylglycine was examined in baby hamster kidney cells which stably express the type I metabotropic glutamate receptor (mGluR1 alpha). DL-4-Carboxy-3-hydroxyphenylglycine dose-dependently inhibited glutamate-stimulated phosphoinositide hydrolysis in a competitive manner with a KB of 29 microM as estimated from Schild-plot analysis. The present report is the first demonstration of a potent and competitive antagonist of the mGluR1 alpha subtype.lld:pubmed
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pubmed-article:8392941pubmed:dateRevised2005-11-17lld:pubmed
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pubmed-article:8392941pubmed:articleTitle4-Carboxy-3-hydroxyphenylglycine, an antagonist at type I metabotropic glutamate receptors.lld:pubmed
pubmed-article:8392941pubmed:affiliationDepartment of Receptor Neurochemistry, Novo Nordisk A/S, Måløv, Denmark.lld:pubmed
pubmed-article:8392941pubmed:publicationTypeJournal Articlelld:pubmed