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rdf:type |
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|
lifeskim:mentions |
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|
pubmed:issue |
3
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pubmed:dateCreated |
1993-8-26
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pubmed:abstractText |
The pharmacology of (DL)-4-carboxy-3-hydroxyphenylglycine was examined in baby hamster kidney cells which stably express the type I metabotropic glutamate receptor (mGluR1 alpha). DL-4-Carboxy-3-hydroxyphenylglycine dose-dependently inhibited glutamate-stimulated phosphoinositide hydrolysis in a competitive manner with a KB of 29 microM as estimated from Schild-plot analysis. The present report is the first demonstration of a potent and competitive antagonist of the mGluR1 alpha subtype.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
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|
pubmed:issn |
0014-2999
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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|
pubmed:volume |
245
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
299-301
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:8392941-Animals,
pubmed-meshheading:8392941-Cell Line,
pubmed-meshheading:8392941-Cricetinae,
pubmed-meshheading:8392941-Dose-Response Relationship, Drug,
pubmed-meshheading:8392941-Excitatory Amino Acid Antagonists,
pubmed-meshheading:8392941-Glycine,
pubmed-meshheading:8392941-Hydrolysis,
pubmed-meshheading:8392941-Phosphatidylinositols,
pubmed-meshheading:8392941-Receptors, Glutamate
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|
pubmed:year |
1993
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|
pubmed:articleTitle |
4-Carboxy-3-hydroxyphenylglycine, an antagonist at type I metabotropic glutamate receptors.
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pubmed:affiliation |
Department of Receptor Neurochemistry, Novo Nordisk A/S, Måløv, Denmark.
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pubmed:publicationType |
Journal Article
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