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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1993-8-26
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pubmed:abstractText |
The effect of male rat sexual behavior on the binding of [3H]-flunitrazepam (FNP) in frontal cortex, hypothalamus and hippocampus was measured. The groups included were: (A) control (no sexual experience) handled males; (B) male rats sacrificed 24 h after their fifth mating experience; (C) males sacrificed 48 h after their fifth mating experience; (D) male rats sacrificed after 5 intromissions during the sixth mating experience; and (E) males sacrificed immediately after the ejaculation during the sixth mating experience. Relative to handled controls, significant decreases in maximal [3H]-FNP binding (Bmax) were observed in frontal cortex and hippocampus of animals sacrificed after 5 intromissions and in frontal cortex of rats sacrificed 24 h after the last mating experience. Relative to males sacrificed after 5 intromissions, males sacrificed immediately after ejaculation exhibited a rapid increase in Bmax in frontal cortex and hippocampus. No between-group differences in Kd for [3H]-FNP were noted, and sexual experience had no effect on the Bmax of [3H]-FNP in the hypothalamus.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
611
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
326-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8392895-Animals,
pubmed-meshheading:8392895-Binding Sites,
pubmed-meshheading:8392895-Cell Membrane,
pubmed-meshheading:8392895-Flunitrazepam,
pubmed-meshheading:8392895-Frontal Lobe,
pubmed-meshheading:8392895-Handling (Psychology),
pubmed-meshheading:8392895-Hippocampus,
pubmed-meshheading:8392895-Hypothalamus,
pubmed-meshheading:8392895-Kinetics,
pubmed-meshheading:8392895-Male,
pubmed-meshheading:8392895-Organ Specificity,
pubmed-meshheading:8392895-Rats,
pubmed-meshheading:8392895-Rats, Sprague-Dawley,
pubmed-meshheading:8392895-Receptors, GABA-A,
pubmed-meshheading:8392895-Sexual Behavior, Animal
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pubmed:year |
1993
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pubmed:articleTitle |
Male rat sexual behavior induces changes in [3H]flunitrazepam binding.
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pubmed:affiliation |
Division de Investigaciones en Neurociencias, Instituto Mexicano de Psiquiatria, CINVESTAV, IPN, D.F.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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