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pubmed:abstractText |
Distamycin A, an oligopeptide antibiotic, supplied at various concentrations for 24 h to human leukocytes in culture, has induced the appearance on some chromosomes of specific areas lacking spiralization. In particular, the centromeric regions of chromosomes 1, 3 and one C-group chromosome and the distal part of the long arm of the Y chromosome were despiralized. The possible nature of these regions is discussed.
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