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rdf:type |
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lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0009015,
umls-concept:C0017262,
umls-concept:C0018787,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205245,
umls-concept:C0205307,
umls-concept:C0288263,
umls-concept:C0475264,
umls-concept:C1711351,
umls-concept:C1979844,
umls-concept:C2911684
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pubmed:issue |
13
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pubmed:dateCreated |
1993-8-6
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pubmed:databankReference |
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pubmed:abstractText |
A unique structural variant of the cardiac L-type voltage-dependent calcium channel alpha 1 subunit cDNA was isolated from libraries derived from normal human heart mRNA. The deduced amino acid sequence shows significant homology to other calcium channel alpha 1 subunits. However, differences from the rabbit heart alpha 1 include a shortened N-terminus, a unique C-terminal insertion, and both forms of an alternatively spliced motif IV S3 region. The shortened N-terminus provides optimal access to consensus sequences thought to facilitate translation. Northern blot analysis revealed a single hybridizing mRNA species of 9.4 kb. The gene for the human heart alpha 1 subunit was localized specifically to the distal region of chromosome 12p13. The cloned alpha 1 subunit was expressed in Xenopus oocytes and single-channel analyses revealed native-like pharmacology and channel properties.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-1316612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-1370480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-1612594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-1648941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-1653763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-1654596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-1664412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-1740331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-1939050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-2169433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-2170396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-2173707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-2412552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-2446390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-2458626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-2474130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-2546809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-3037387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-3344216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8392192-6314245
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
6228-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8392192-Amino Acid Sequence,
pubmed-meshheading:8392192-Animals,
pubmed-meshheading:8392192-Base Sequence,
pubmed-meshheading:8392192-Blotting, Northern,
pubmed-meshheading:8392192-Calcium Channels,
pubmed-meshheading:8392192-Chromosome Mapping,
pubmed-meshheading:8392192-Chromosomes, Human, Pair 12,
pubmed-meshheading:8392192-Cloning, Molecular,
pubmed-meshheading:8392192-Cricetinae,
pubmed-meshheading:8392192-DNA,
pubmed-meshheading:8392192-Humans,
pubmed-meshheading:8392192-In Situ Hybridization,
pubmed-meshheading:8392192-Molecular Sequence Data,
pubmed-meshheading:8392192-Myocardium,
pubmed-meshheading:8392192-Rabbits,
pubmed-meshheading:8392192-Rats
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pubmed:year |
1993
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pubmed:articleTitle |
Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart.
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pubmed:affiliation |
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, OH 45267-0575.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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