Linked Life Data

8391958

Source:http://linkedlifedata.com/resource/pubmed/id/8391958

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-8-6
pubmed:abstractText
One type of motor neuron disease (MND) associated with dementia is well known for the fact that it displays atrophy of the frontal and temporal lobes, neuronal loss and sponginess of the superficial layers of the cortex, and subcortical gliosis (so-called Mitsuyama type). In an attempt to determine characteristics of the pathology of motor neurons, three cases of MND with dementia were examined and compared with 16 cases of sporadic classical amyotrophic lateral sclerosis (ALS) with light and electron microscopes. All these cases with dementia showed loss of motor neurons, chromatolysis, spheroids, and Bunina bodies. Quantitative analyses of the 5th lumbar anterior horns showed no significant differences in incidences of chromatolysis and Bunina bodies between cases with and without dementia. Ultrastructures of the anterior horns were essentially identical in both groups. Therefore, the pathology of motor neurons at least in one type of MND with dementia seems to share common features with that in sporadic classical ALS without dementia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0722-5091
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
164-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Pathology of motor neurons in amyotrophic lateral sclerosis with dementia.
pubmed:affiliation
Department of Neurology, Kitano Hospital, Osaka, Japan.
pubmed:publicationType
Journal Article, Case Reports