Linked Life Data

8391596

Source:http://linkedlifedata.com/resource/pubmed/id/8391596

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-8-3
pubmed:abstractText
To clarify the role of Na(+)-H+ antiporter as a subcellular signal in cardiovascular system, we determined mRNA levels of the Na(+)-H+ antiporter in the vascular smooth muscles and pressure-overloaded hearts in rabbits. The expression of the Na(+)-H+ antiporter gene in rabbit aortas and hearts was much more prominent at embryonic and neonatal stages than in adults. The growth of C5, which is deficient in the Na(+)-H+ antiporter, was accelerated again when the activity was restored by transfecting cells with full-length cDNA for Na(+)-H+ antiporter in an expression vector. In pressure-overloaded hearts, the Na(+)-H+ antiporter mRNA was increased 2.5 fold of sham-operated rabbits at 3 days after aortic constriction, lasting for more than 2 weeks. We conclude from these results that activation of the Na(+)-H+ antiporter gene plays a key role in both cardiac hypertrophy and vascular smooth muscle cell proliferation.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1518-23
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Activation of Na(+)-H+ antiporter gene expression during vascular smooth muscle proliferation and cardiac hypertrophy].
pubmed:affiliation
Laboratory Medicine, University of Tokyo.
pubmed:publicationType
Journal Article, English Abstract, Review