Linked Life Data

8391089

Source:http://linkedlifedata.com/resource/pubmed/id/8391089

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-7-27
pubmed:abstractText
We examined the effects of ketamine (20 mg.kg-1) on plasma ACTH, Comp. B, aldosterone and ir-ANP levels in unstrained rats. We divided rats into two groups, saline group as control (saline group) and ketamine group (ketamine treated rats). Plasma samples were taken before ketamine or saline infusion to determine a pre-treatment value, and samples were also taken at 15, 30, 60 minutes after the infusion. ACTH, aldosterone and ir-ANP were measured by radioimmunoassay. Comp. B was determined by a fluorometric method. We obtained the following results: 1) Plasma ACTH levels increased significantly in the ketamine group, while there was no such a marked increase in the saline group. The slight increase in ACTH in the saline group could have resulted from handling during i.v. infusion or psychic stress; 2) Plasma corticosterone and aldosterone levels increased markedly in both groups. However, the magnitude of the adrenocortical response was significantly greater than in the saline group; 3) Plasma ir-ANP showed no significant change in both groups. These results suggest that ketamine stimulated pituitary-adrenal axis, and the adrenal stimulation produced by ketamine are greater than those induced by the stress of handling or psychic stress.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-4892
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
552-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Effects of ketamine on pituitary-adrenal axis in rats].
pubmed:affiliation
Department of Anesthesiology, University of Hirosaki School of Medicine.
pubmed:publicationType
Journal Article, English Abstract