Linked Life Data

8391074

Source:http://linkedlifedata.com/resource/pubmed/id/8391074

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-7-27
pubmed:abstractText
Twenty-five pleomorphic adenomas and 10 normal salivary glands were immunohistochemically studied with respect to cytoskeletal proteins and extracellular matrix components to observe the relationship between these components and the differentiation of tumor cells in pleomorphic adenomas. For immunohistochemical observation, keratin (AE1), vimentin (V9), alpha-smooth muscle actin (1A4) and type IV collagen (JK-199) were studied by means of monoclonal antibodies, and laminin (LM) and fibronectin (FN) were analysed with polyclonal antibodies. AE1 was localized in inner tubular cells, and 1A4 was identified in spindle and leiomyomatous cells. These observations may provide evidence of differentiation into ductal epithelia and myoepithelial cells, respectively. Positive staining for V9 in cuboidal cells suggests dedifferentiation. The extracellular matrix components, JK-199, LM and FN, were localized in surrounding areas of cells stained by V9 and/or 1A4. This suggests that expression of these cytoskeletal proteins and extracellular matrix components may affect each other, and ther by contribute to cellular differentiation and production of extracellular matrix.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0030-6622
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
780-6
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Immunohistopathological properties of cytoskeletal proteins and extracellular matrix components in pleomorphic adenomas of salivary glands].
pubmed:affiliation
Department of Pathology, Nippon Medical School, Tokyo.
pubmed:publicationType
Journal Article, English Abstract