|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1993-7-23
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|
pubmed:abstractText |
Cone biopsies were carried out in patients (n = 72) with intraepithelial lesions (CIN 1-3) and squamous microinvasive carcinomas of the uterine cervix. Intraoperative histological examination was achieved in order to obtain small cones with healthy upper resection margins. Also, a tissue fragment was sampled and frozen for the immunocytochemical investigations. Image analysis (SAMBA) of immunoprecipitates was used to evaluate c-myc and Ki-67 antigen expression. Positive c-myc protein staining was observed only on microinvasive carcinomas (70%) and CIN 3 lesions (19%) and was correlated with high Ki-67 immunoreactivity. Ki-67 immunostaining was more extensive: (i) in high-grade than low-grade CIN, (ii) in microinvasive carcinomas than in CIN (P < or = 0.01), (iii) in large than in small lesions. No correlation could be found between the levels of either c-myc protein or Ki-67 antigen expression and either patient age or cytological features of HPV infection.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0090-8258
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
49
|
|
pubmed:geneSymbol |
c-myc
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
284-90
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|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8390959-Adult,
pubmed-meshheading:8390959-Aged,
pubmed-meshheading:8390959-Antibodies, Monoclonal,
pubmed-meshheading:8390959-Carcinoma,
pubmed-meshheading:8390959-Carcinoma, Squamous Cell,
pubmed-meshheading:8390959-DNA Probes, HPV,
pubmed-meshheading:8390959-Female,
pubmed-meshheading:8390959-Humans,
pubmed-meshheading:8390959-Immunoenzyme Techniques,
pubmed-meshheading:8390959-In Situ Hybridization,
pubmed-meshheading:8390959-Ki-67 Antigen,
pubmed-meshheading:8390959-Middle Aged,
pubmed-meshheading:8390959-Neoplasm Proteins,
pubmed-meshheading:8390959-Nuclear Proteins,
pubmed-meshheading:8390959-Papillomaviridae,
pubmed-meshheading:8390959-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:8390959-Statistics as Topic,
pubmed-meshheading:8390959-Tumor Virus Infections,
pubmed-meshheading:8390959-Uterine Cervical Neoplasms
|
|
pubmed:year |
1993
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|
pubmed:articleTitle |
c-myc protein and Ki-67 antigen immunodetection in patients with uterine cervix neoplasia: correlation of microcytophotometric analysis and histological data.
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|
pubmed:affiliation |
DRED Unit (Human solid tumor oncogenesis), Centre Hospitalo-Universitaire Timone, Marseille, France.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
