Linked Life Data

839071

Source:http://linkedlifedata.com/resource/pubmed/id/839071

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1977-4-15
pubmed:abstractText
Athymic nude mice (Nu/Nu), heterozygous littermates (Nu/+), and thymus reconstituted homozygous animals (Nu/Nu TXR) were exposed to Schistosoma mansoni cercariae. A marked impairment in the development of peripheral blood eosinophilia and hepatic granuloma was observed in the Nu/Nu animal. In addition, host morbidity judged by organ weight, portal pressures and reticuloendothelial activity were less in the Nu/Nu animal. Thymus-reconstituted animals demonstrated eosinophilia, increased granuloma size, and morbidity equivalent to that shown by the Nu/+ heterozygous littermates. These studies indicate that the eosinophilia, granulomatous hypersensitivity, and ultimate host morbidity, associated with murine schistosomiasis, is dependent on thymic dependent lymphocyte function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
594-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Schistosomiasis in the congenitally athymic (nude) mouse. I. Thymic dependency of eosinophilia, granuloma formation, and host morbidity.
pubmed:publicationType
Journal Article