Linked Life Data

8389612

Source:http://linkedlifedata.com/resource/pubmed/id/8389612

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-7-15
pubmed:abstractText
A previous study of coralline hydroxyapatite as a bone-graft substitute was extended from 4 to 12 months to determine better the relationships between implantation time, bone ingrowth and mechanical properties. The model consisted of a 10 x 30 mm window defect in the shaft of the canine radius (a cortical site), and a 10 mm diameter cylindrical defect in the head of the humerus (a cancellous site). In the new study, these two defects were made bilaterally in eight dogs, and filled with block-form coralline hydroxyapatite. The radius defects were supported by a metal fixation plate which was removed after 9 months. After 12 months, the dogs were killed and the left-side implants were analyzed histomorphometrically and mechanically. The right-side radius and humerus were reserved for structural analysis. The results were combined with those previously measured after 4, 8, 12 and 16 wk of implantation. In the cortical site, bone ingrowth increased from 52% at 16 wk to 74% at 1 yr. In the cancellous site, bone ingrowth was 38% after 4 wk, then fell monotonically, reaching 17% at 1 yr. Bending and compressive strength and stiffness of the radius implants increased throughout the post-implantation year, but compressive strength and stiffness of the humerus implants did not change after the first 2-4 months. Mechanical properties were strongly correlated to bone ingrowth in the cortical, but not the cancellous, site. The volume fraction of the coralline hydroxyapatite material diminished significantly with time in the cortical, but not the cancellous, site.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
341-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Bone ingrowth and mechanical properties of coralline hydroxyapatite 1 yr after implantation.
pubmed:affiliation
Orthopaedic Research Laboratory, University of California, Davis 95616.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't