| pubmed-article:8389466 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8389466 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:8389466 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8389466 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:8389466 | lifeskim:mentions | umls-concept:C1418939 | lld:lifeskim |
| pubmed-article:8389466 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:8389466 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8389466 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8389466 | pubmed:dateCreated | 1993-7-7 | lld:pubmed |
| pubmed-article:8389466 | pubmed:abstractText | Protamines are small arginine-rich proteins that package DNA in spermatozoa. The mouse protamine 1 (Prm-1) gene is transcribed exclusively in post-meiotic spermatids. To identify elements in the Prm-1 promoter required for spermatid-specific transcription, we generated transgenic mice by microinjection of transgenes containing Prm-1 5' flanking sequences with 5' truncations or internal deletions of conserved sequences linked to a marked Prm-1 gene. We also tested Prm-1 promoter regions with a heterologous human growth hormone reporter gene. We conclude that a 113-bp region can direct spermatid-specific transcription and we have defined sequences within this region that are essential for proper function. These results will facilitate the isolation and characterization of transcription factors essential for post-meiotic gene expression. | lld:pubmed |
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| pubmed-article:8389466 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8389466 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8389466 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8389466 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8389466 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8389466 | pubmed:author | pubmed-author:BrinsterR LRL | lld:pubmed |
| pubmed-article:8389466 | pubmed:author | pubmed-author:PalmiterR DRD | lld:pubmed |
| pubmed-article:8389466 | pubmed:author | pubmed-author:ZimmermannJ... | lld:pubmed |
| pubmed-article:8389466 | pubmed:author | pubmed-author:HarendzaC JCJ | lld:pubmed |
| pubmed-article:8389466 | pubmed:author | pubmed-author:ZambrowiczB... | lld:pubmed |
| pubmed-article:8389466 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8389466 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8389466 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:8389466 | pubmed:geneSymbol | Prm-1 | lld:pubmed |
| pubmed-article:8389466 | pubmed:geneSymbol | Prm-2 | lld:pubmed |
| pubmed-article:8389466 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8389466 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8389466 | pubmed:pagination | 5071-5 | lld:pubmed |
| pubmed-article:8389466 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8389466 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8389466 | pubmed:articleTitle | Analysis of the mouse protamine 1 promoter in transgenic mice. | lld:pubmed |
| pubmed-article:8389466 | pubmed:affiliation | Howard Hughes Medical Institute, University of Washington, Seattle 98195. | lld:pubmed |
| pubmed-article:8389466 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8389466 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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