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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1993-7-2
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pubmed:abstractText |
The Epstein-Barr viral transcriptional activator ZEBRA induces expression of viral early lytic genes when introduced into cells bearing latent Epstein-Barr virus. We show here that a ZEBRA-herpes simplex viral protein 16 (VP16) fusion protein induces early viral lytic gene expression in Epstein-Barr virus-containing cells more efficiently than does wild-type ZEBRA. The fusion protein is also a more powerful transcriptional activator in these cells, as assayed with reporter constructs. Our experiments also suggest that ZEBRA manifests a function required for full activity on certain natural promoters but not on promoters bearing oligomerized ZEBRA binding sites; this function cannot be provided by VP16.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-1309920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-1321270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-1326406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-1532252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-1649314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-1851554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2154605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2154606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2157769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2157874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2159531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2161945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2164595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2174563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2370859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2536096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2538653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2540954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2542612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2542618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2548003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2820125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2823252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2830986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2830987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2834649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2841949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2842768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2843425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2987963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-2994050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-3028777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-3032451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-3047590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-3050531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-6096556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-6298741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8389449-6960240
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4436-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8389449-Cells, Cultured,
pubmed-meshheading:8389449-DNA-Binding Proteins,
pubmed-meshheading:8389449-Gene Expression Regulation, Viral,
pubmed-meshheading:8389449-Herpesvirus 4, Human,
pubmed-meshheading:8389449-Humans,
pubmed-meshheading:8389449-Protein Binding,
pubmed-meshheading:8389449-RNA, Messenger,
pubmed-meshheading:8389449-Recombinant Fusion Proteins,
pubmed-meshheading:8389449-Structure-Activity Relationship,
pubmed-meshheading:8389449-Trans-Activators,
pubmed-meshheading:8389449-Transcription Factors,
pubmed-meshheading:8389449-Transcriptional Activation,
pubmed-meshheading:8389449-Viral Proteins,
pubmed-meshheading:8389449-Virus Replication
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pubmed:year |
1993
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pubmed:articleTitle |
Changing Epstein-Barr viral ZEBRA protein into a more powerful activator enhances its capacity to disrupt latency.
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pubmed:affiliation |
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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