|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1993-6-17
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|
pubmed:abstractText |
Mitogen-activated protein (MAP) kinases are activated by combined tyrosine and threonine phosphorylation catalysed by MAP kinase kinase, a novel class of protein kinases with dual specificity for both tyrosine and serine/threonine. MAP kinase kinase is turned on by serine/threonine phosphorylation catalysed by an immediate upstream kinase. The MAP kinase cascade appears to be conserved during evolution and thus might play an essential role in diverse intracellular signaling processes from yeasts to vertebrates.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0968-0004
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
128-31
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|
pubmed:dateRevised |
2009-11-19
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|
pubmed:meshHeading |
pubmed-meshheading:8388132-Amino Acid Sequence,
pubmed-meshheading:8388132-Animals,
pubmed-meshheading:8388132-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:8388132-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:8388132-Molecular Sequence Data,
pubmed-meshheading:8388132-Phosphorylation,
pubmed-meshheading:8388132-Protein Kinases,
pubmed-meshheading:8388132-Saccharomyces cerevisiae,
pubmed-meshheading:8388132-Schizosaccharomyces,
pubmed-meshheading:8388132-Signal Transduction,
pubmed-meshheading:8388132-Xenopus
|
|
pubmed:year |
1993
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|
pubmed:articleTitle |
The MAP kinase cascade is essential for diverse signal transduction pathways.
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|
pubmed:affiliation |
Department of Biophysics, Faculty of Science, University of Tokyo, Japan.
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|
pubmed:publicationType |
Journal Article,
Review
|
