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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5111
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pubmed:dateCreated |
1993-6-16
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pubmed:databankReference |
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pubmed:abstractText |
Oscillatory firing patterns are an intrinsic property of some neurons and have an important function in information processing. In some cells, low voltage-activated calcium channels have been proposed to underlie a depolarizing potential that regulates bursting. The sequence of a rat brain calcium channel alpha 1 subunit (rbE-II) was deduced. Although it is structurally related to high voltage-activated calcium channels, the rbE-II channel transiently activated at negative membrane potentials, required a strong hyperpolarization to deinactivate, and was highly sensitive to block by nickel. In situ hybridization showed that rbE-II messenger RNA is expressed in regions throughout the central nervous system. The electrophysiological properties of the rbE-II current are consistent with a type of low voltage-activated calcium channel that requires membrane hyperpolarization for maximal activity, which suggests that rbE-II may be involved in the modulation of firing patterns.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
260
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1133-6
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:8388125-Amino Acid Sequence,
pubmed-meshheading:8388125-Animals,
pubmed-meshheading:8388125-Brain Chemistry,
pubmed-meshheading:8388125-Calcium Channels,
pubmed-meshheading:8388125-Calcium Channels, R-Type,
pubmed-meshheading:8388125-Cation Transport Proteins,
pubmed-meshheading:8388125-Cloning, Molecular,
pubmed-meshheading:8388125-Electric Conductivity,
pubmed-meshheading:8388125-Hippocampus,
pubmed-meshheading:8388125-In Situ Hybridization,
pubmed-meshheading:8388125-Membrane Potentials,
pubmed-meshheading:8388125-Membrane Proteins,
pubmed-meshheading:8388125-Molecular Sequence Data,
pubmed-meshheading:8388125-Nerve Tissue Proteins,
pubmed-meshheading:8388125-RNA, Messenger,
pubmed-meshheading:8388125-Rats,
pubmed-meshheading:8388125-Sequence Alignment
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pubmed:year |
1993
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pubmed:articleTitle |
Structure and functional expression of a member of the low voltage-activated calcium channel family.
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pubmed:affiliation |
Biotechnology Laboratory, University of British Columbia, Vancouver, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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