|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0035820,
umls-concept:C0087049,
umls-concept:C0330390,
umls-concept:C0337112,
umls-concept:C0814999,
umls-concept:C1511545,
umls-concept:C1511695,
umls-concept:C1524075,
umls-concept:C1527148,
umls-concept:C1880371
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1993-6-11
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Thymocytes from mice congenitally deficient for TCR alpha chain synthesis were examined for the status of their TCR beta chain genes, by DNA sequencing and by a novel technique that analyzes populations of gene rearrangements. TCR beta chain genes were predominantly productively rearranged, in contrast with the statistical prediction for a quasi-random rearrangement process. Therefore, productive TCR beta chain gene rearrangement appears to be a critical step in thymocyte maturation, independent of TCR alpha chain expression. Moreover, the beta chain gene rearrangements in TCR alpha-/-mice are typical of those found in the thymus and periphery of normal mice. Thus, the extent of junctional diversity is a property of TCR genes that is imposed prior to selection on the mature alpha beta TCR.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0092-8674
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
7
|
|
pubmed:volume |
73
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
513-9
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:8387894-Animals,
pubmed-meshheading:8387894-Base Sequence,
pubmed-meshheading:8387894-Blotting, Southern,
pubmed-meshheading:8387894-Cloning, Molecular,
pubmed-meshheading:8387894-DNA,
pubmed-meshheading:8387894-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:8387894-Genetic Variation,
pubmed-meshheading:8387894-Genotype,
pubmed-meshheading:8387894-Mice,
pubmed-meshheading:8387894-Mice, Mutant Strains,
pubmed-meshheading:8387894-Molecular Sequence Data,
pubmed-meshheading:8387894-Oligodeoxyribonucleotides,
pubmed-meshheading:8387894-Polymerase Chain Reaction,
pubmed-meshheading:8387894-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8387894-Restriction Mapping,
pubmed-meshheading:8387894-T-Lymphocytes,
pubmed-meshheading:8387894-Thymus Gland
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Rearrangement and diversity of T cell receptor beta chain genes in thymocytes: a critical role for the beta chain in development.
|
|
pubmed:affiliation |
Department of Biology, Yale University, New Haven, Connecticut 06511.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
