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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-6-11
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pubmed:abstractText |
The multiple biological activities of tumor necrosis factor (TNF) are mediated by two distinct cell surface receptors of 55 kd (TNFRp55) and 75 kd (TNFRp75). Using gene targeting, we generated a TNFRp55-deficient mouse strain. Cells from TNFRp55-/-mutant mice lack expression of TNFRp55 but display normal numbers of high affinity TNFRp75 molecules. Thymocyte development and lymphocyte populations are unaltered, and clonal deletion of potentially self-reactive T cells is not impaired. However, TNF signaling is largely abolished, as judged by the failure of TNF to induce NF-kappa B in T lymphocytes from TNFRp55-deficient mice. The loss of TNFRp55 function renders mice resistant to lethal dosages of either lipopolysaccharides or S. aureus enterotoxin B. In contrast, TNFRp55-deficient mice are severely impaired to clear L. monocytogenes and readily succumb to infection. Thus, the 55 kd TNFR plays a decisive role in the host's defense against microorganisms and their pathogenic factors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
457-67
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8387893-Animals,
pubmed-meshheading:8387893-Base Sequence,
pubmed-meshheading:8387893-Cell Nucleus,
pubmed-meshheading:8387893-Cloning, Molecular,
pubmed-meshheading:8387893-Humans,
pubmed-meshheading:8387893-Immunity, Innate,
pubmed-meshheading:8387893-Kinetics,
pubmed-meshheading:8387893-Lipopolysaccharides,
pubmed-meshheading:8387893-Listeriosis,
pubmed-meshheading:8387893-Liver,
pubmed-meshheading:8387893-Lymphocytes,
pubmed-meshheading:8387893-Mice,
pubmed-meshheading:8387893-Mice, Mutant Strains,
pubmed-meshheading:8387893-Molecular Sequence Data,
pubmed-meshheading:8387893-Molecular Weight,
pubmed-meshheading:8387893-NF-kappa B,
pubmed-meshheading:8387893-Oligodeoxyribonucleotides,
pubmed-meshheading:8387893-Polymerase Chain Reaction,
pubmed-meshheading:8387893-Radioligand Assay,
pubmed-meshheading:8387893-Receptors, Cell Surface,
pubmed-meshheading:8387893-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:8387893-Shock, Septic,
pubmed-meshheading:8387893-Transfection,
pubmed-meshheading:8387893-Tumor Necrosis Factor-alpha
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pubmed:year |
1993
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pubmed:articleTitle |
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.
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pubmed:affiliation |
Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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