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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1993-6-3
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pubmed:abstractText |
The neurosteroids, pregnenolone sulfate (PREG-S) and tetrahydroprogesterone (TH-PROG), act on the GABAA receptor with antagonist or agonist-like properties, respectively. In this study the effect of the infusion of PREG-S and TH-PROG into the nucleus basalis magnocellularis (NBM) of the rat was examined in a two-trial memory task. The results show that PREG-S (5 ng in 0.5 microliter) enhances memory performance when injected after an acquisition trial; conversely TH-PROG (2 ng in 0.5 microliter) disrupts performance when injected before an acquisition trial. A role for neurosteroids in memory processes subserved by the nucleus basalis magnocellularis is of interest in view of the implication of this structure and these substances in neurodegenerative processes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
607
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
324-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8386975-Animals,
pubmed-meshheading:8386975-Basal Ganglia,
pubmed-meshheading:8386975-Cognition,
pubmed-meshheading:8386975-Conditioning, Operant,
pubmed-meshheading:8386975-Exploratory Behavior,
pubmed-meshheading:8386975-GABA-A Receptor Antagonists,
pubmed-meshheading:8386975-Injections,
pubmed-meshheading:8386975-Male,
pubmed-meshheading:8386975-Memory,
pubmed-meshheading:8386975-Pregnanolone,
pubmed-meshheading:8386975-Pregnenolone,
pubmed-meshheading:8386975-Rats,
pubmed-meshheading:8386975-Rats, Sprague-Dawley,
pubmed-meshheading:8386975-Receptors, GABA-A,
pubmed-meshheading:8386975-Steroids
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pubmed:year |
1993
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pubmed:articleTitle |
Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat.
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pubmed:affiliation |
Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM Unité 259, Université de Bordeaux II, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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