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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1993-5-24
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pubmed:abstractText |
We have purified biologically active recombinant human fibroblast growth factor 5 (FGF-5) from Escherichia coli. In the presence of heparin, recombinant FGF-5 is as active as native growth factor, demonstrating that glycosylation does not significantly potentiate FGF-5 activity. FGF-5 can bind and induce autophosphorylation of human FGF receptors (FGFR) 1 and 2. Competition binding studies show that the KD for FGF-5-FGFR-1 and FGF-5-FGFR-2 interactions are both between 0.5 and 1.5 x 10(-9) M.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/FGF5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/FGFR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fgf5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fgfr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 5,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Fibroblast Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fibroblast Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0950-9232
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1311-6
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pubmed:dateRevised |
2010-5-26
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pubmed:meshHeading |
pubmed-meshheading:8386828-3T3 Cells,
pubmed-meshheading:8386828-Amino Acid Sequence,
pubmed-meshheading:8386828-Animals,
pubmed-meshheading:8386828-Base Sequence,
pubmed-meshheading:8386828-Fibroblast Growth Factor 5,
pubmed-meshheading:8386828-Fibroblast Growth Factors,
pubmed-meshheading:8386828-Humans,
pubmed-meshheading:8386828-Mice,
pubmed-meshheading:8386828-Molecular Sequence Data,
pubmed-meshheading:8386828-Phosphorylation,
pubmed-meshheading:8386828-Receptor, Fibroblast Growth Factor, Type 1,
pubmed-meshheading:8386828-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:8386828-Receptors, Cell Surface,
pubmed-meshheading:8386828-Receptors, Fibroblast Growth Factor,
pubmed-meshheading:8386828-Recombinant Proteins
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pubmed:year |
1993
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pubmed:articleTitle |
Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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