Linked Life Data

8386739

Source:http://linkedlifedata.com/resource/pubmed/id/8386739

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-5-25
pubmed:abstractText
To evaluate the potential role of viruses in the pathogenesis of hypersensitivity pneumonitis (HP), we looked at the effect of challenging normal versus Sendai-injected mice with Saccharopolyspora rectivirgula (SR). In this model of HP, mice are nasally instilled with SR antigen three consecutive days per week of study. For this study virus was given after 3 weeks of SR. Two positive (SR alone, virus alone) and a negative (saline) control groups were done in parallel with the viral plus SR group. Lung response to these different conditions was evaluated by lung index, bronchoalveolar lavage (BAL) cell populations, lung histopathology, and BAL fluid fibronectin levels. SR challenge resulted in an increase in BAL cells, lung index, and BAL fibronectin levels and in a peribronchial inflammatory reaction. The virus alone produced a transient increase in BAL cells. The cellular response to SR, in virus-injected animals, was greater than the added effects of the virus and SR. Virus alone had no persistent effect on the other measured parameters and did not change the effect of SR on these variables. We conclude that the Sendai virus enhances the cellular response of the mouse lungs to an SR antigenic challenge.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-2143
pubmed:author
pubmed:issnType
Print
pubmed:volume
121
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
683-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Modulation of experimental hypersensitivity pneumonitis by Sendai virus.
pubmed:affiliation
Unité de recherche, Centre de pneumologie de l'Hôpital Laval, Université Laval, Québec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't