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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-5-14
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pubmed:abstractText |
Perfluorooctane sulfonic acid is almost as potent as perfluorooctanoic acid in causing increases in peroxisomal fatty acid beta-oxidation, peroxisomal catalase activity, omega-hydroxylation of lauric acid, cytosolic epoxide hydrolase activity and cytosolic DT-diaphorase activity. Octane sulfonic acid was ineffective at doses used for perfluorooctane sulfonic acid and perfluorooctanoic acid. The results support the theory of co-regulation of these parameters and peroxisome proliferation. The fact that perfluorooctane sulfonic acid causes peroxisome proliferation challenges the hypothesis that the first step in this process is formation of a thioester between the proliferator (the carboxylic group) and coenzyme A.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0901-9928
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
90-3
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8386358-Acyl Coenzyme A,
pubmed-meshheading:8386358-Alkanesulfonates,
pubmed-meshheading:8386358-Alkanesulfonic Acids,
pubmed-meshheading:8386358-Animals,
pubmed-meshheading:8386358-Body Weight,
pubmed-meshheading:8386358-Cytosol,
pubmed-meshheading:8386358-Diet,
pubmed-meshheading:8386358-Fatty Acids,
pubmed-meshheading:8386358-Fluorocarbons,
pubmed-meshheading:8386358-Hypolipidemic Agents,
pubmed-meshheading:8386358-Liver,
pubmed-meshheading:8386358-Male,
pubmed-meshheading:8386358-Mice,
pubmed-meshheading:8386358-Mice, Inbred C57BL,
pubmed-meshheading:8386358-Microbodies,
pubmed-meshheading:8386358-Microsomes, Liver,
pubmed-meshheading:8386358-Organ Size,
pubmed-meshheading:8386358-Oxidation-Reduction,
pubmed-meshheading:8386358-Xenobiotics
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pubmed:year |
1993
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pubmed:articleTitle |
Perfluorooctane sulfonic acid is a potent inducer of peroxisomal fatty acid beta-oxidation and other activities known to be affected by peroxisome proliferators in mouse liver.
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pubmed:affiliation |
Department of Biochemistry, Wallenberg Laboratory, Stockholm University, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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