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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1993-5-17
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pubmed:abstractText |
We examined the effects of glutamate receptor agonists on cyclic AMP (cAMP) formation in cultured astrocytes. L-Glutamate reduced the cAMP formation induced by either isoproterenol (IC50 7 microM) or forskolin without affecting the basal level. Glutamate agonists reduced the cAMP formation in astrocytes with the following rank order of potency: L-glutamate > trans-(+/-)-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) = quisqualate. Pretreatment of astrocytes with pertussis toxin resulted in a partial reduction of the glutamate response and a complete attenuation of the t-ACPD response. These results suggest that astrocytes have another type of metabotropic glutamate receptor which inhibits adenylate cyclase through pertussis toxin-sensitive G-proteins.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-amino-1,3-dicarboxycyclopentane,
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloleucine,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Quisqualic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors, Bordetella
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
149
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
182-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8386346-Adenylate Cyclase Toxin,
pubmed-meshheading:8386346-Animals,
pubmed-meshheading:8386346-Animals, Newborn,
pubmed-meshheading:8386346-Astrocytes,
pubmed-meshheading:8386346-Cells, Cultured,
pubmed-meshheading:8386346-Cyclic AMP,
pubmed-meshheading:8386346-Cycloleucine,
pubmed-meshheading:8386346-Excitatory Amino Acid Antagonists,
pubmed-meshheading:8386346-Forskolin,
pubmed-meshheading:8386346-Iodine Radioisotopes,
pubmed-meshheading:8386346-Isoproterenol,
pubmed-meshheading:8386346-Pertussis Toxin,
pubmed-meshheading:8386346-Quisqualic Acid,
pubmed-meshheading:8386346-Rats,
pubmed-meshheading:8386346-Rats, Sprague-Dawley,
pubmed-meshheading:8386346-Receptors, Glutamate,
pubmed-meshheading:8386346-Virulence Factors, Bordetella
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pubmed:year |
1993
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pubmed:articleTitle |
Inhibitory glutamate response on cyclic AMP formation in cultured astrocytes.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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