Linked Life Data

838521

Source:http://linkedlifedata.com/resource/pubmed/id/838521

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1977-4-25
pubmed:abstractText
Lymphoid cells from normal W/Fu rats are cytotoxic in vitro for syngeneic Gross-virus-induced lymphoma cells in a 4 1/2 h 51Cr release test, and protect against tumour growth in vivo when adoptively transferred to syngeneic recipient rats. Cytotoxicity by normal lymphoid cells was greater with in vitro rather than in vivo passaged target cells, and was increased by preincubation of the lymphoid cells at 37 degrees C for 3 h in vitro before their addition to the target cells. Cytotoxic activity, which was localized predominantly in the spleen, was absent at birth but increased until adulthood with some decline in older age. Histocompatibility at the major Ag-B locus was not required for the killer cell--target cell interaction; normal spleen cells of many Ag-B genotypes were cytotoxic for W/FuG-1 target cells, although BDIX and (BDIX X W/Fu)F1 were less active and BN were inactive. The specificity of cytotoxicity was studied by the techniques of direct lysis, competitive inhibition or adsorption to cellular monolayers, using a variety of cell lines. Selectively of lysis or binding was observed and was restricted to rat target cells releasing exogenous or endogenous C-type viruses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0020-7136
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
212-24
pubmed:dateRevised
2007-7-24
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Gross-virus-induced lymphoma in the rat. IV. Cytotoxic cells in normal rats.
pubmed:publicationType
Journal Article