Linked Life Data

8384095

Source:http://linkedlifedata.com/resource/pubmed/id/8384095

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-4-19
pubmed:abstractText
GABA (gamma-aminobutyric acid) can modulate axonal excitability by activating GABAA receptors on some central nervous system axons. The effects of GABA on optic nerve axons decrease significantly during the course of myelination, suggesting that myelination may influence changes in GABA sensitivity. To test this hypothesis, we compared the depolarizing effect of GABA and the GABAA-receptor agonist, muscimol, on optic nerves of myelin-deficient (MD) rats and their unaffected siblings using a modified sucrose-gap technique. Optic nerves from both control and MD rats displayed relatively large GABA-induced depolarizations when studied at an early postnatal period. In both the control and MD rats, the GABA uptake inhibitor nipecotic acid led to a distinct depolarization suggesting endogenous release of GABA. Although the GABA-induced depolarization in the MD rat was significantly greater than that in the control rat at the third postnatal week, the response in the MD rat attenuated with maturation. These results demonstrate that the attenuation of the depolarization induced by GABA and nipecotic acid seen in the normal optic nerve also occurs in the MD rat optic nerve. This suggests that the attenuation of optic nerve sensitivity to GABA is not the result of myelination or interaction with myelin-associated proteins.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The attenuation of GABA sensitivity in the maturing myelin-deficient rat optic nerve.
pubmed:affiliation
Department of Neurology, Yale University School of Medicine, New Haven, CT 06510.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't