Linked Life Data

8383741

Source:http://linkedlifedata.com/resource/pubmed/id/8383741

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-4-14
pubmed:abstractText
The immunosuppressive effects following acute morphine administration have been mapped to opioid receptors in the central nervous system, specifically to the periaqueductal gray matter of the mesencephalon. The mesencephalon is associated with sympathetic neuronal processes, and the spleen is innervated with sympathetic neurons that are in direct apposition with lymphocytes in the periarteriolar lymphatic sheath. Accordingly, we investigated adrenergic involvement following morphine administration on natural killer (NK) activity by splenic lymphocytes. Acute morphine administration (25 mg/kg s.c.) suppresses (30-50%) NK activity by murine splenic immunocytes as measured in a 4-hr 51Cr-release assay. The suppression is blocked by phentolamine (4 mg/kg) and propranolol (10 mg/kg) in a dose-dependent fashion. However, phentolamine (2 mg/kg), but not propranolol (5 mg/kg), can also effectively antagonize morphine-induced immunosuppression. In addition, phentolamine (4 mg/kg) and prazocin (1 mg/kg), but not yohimbine (1 mg/kg), antagonizes morphine-elicited suppression of splenic NK activity. Selective opioid receptor antagonists were also utilized to determine the type or subtype of receptor activated following morphine administration. beta-Funaltrexamine (40 mg/kg) but not naloxonazine (35 mg/kg), naltrindole (20 mg/kg) or norbinaltorphimine (10 mg/kg) effectively blocks morphine-induced suppression of splenic NK activity. Collectively, morphine interacts with 1) mu-2 opioid receptors (most probably centrally) and 2) activates both alpha and beta adrenergic pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
264
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1179-86
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Alpha adrenergic and mu-2 opioid receptors are involved in morphine-induced suppression of splenocyte natural killer activity.
pubmed:affiliation
Department of Microbiology, Immunology and Parasitology, Louisiana State University Medical Center, New Orleans.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't