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rdf:type |
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lifeskim:mentions |
umls-concept:C0002062,
umls-concept:C0020923,
umls-concept:C0032699,
umls-concept:C0064847,
umls-concept:C0214374,
umls-concept:C0231491,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1218173,
umls-concept:C1334350,
umls-concept:C1552599,
umls-concept:C1704787
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pubmed:issue |
1
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pubmed:dateCreated |
1993-4-15
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pubmed:abstractText |
Three new imidazole alkaloids, leucettamines A [1] and B [2] and leucettamidine [3], have been isolated from the Palauan sponge Leucetta microraphis. Their structures were established on the basis of extensive spectral analyses. Leucettamine A showed potent leukotriene B4 receptor binding activity (K(i) = 1.3 microM), while leucettamine B was essentially inactive (K(i) = 100 microM) and leucettamidine showed significant activity (K(i) = 5.3 microM). With leucettamine A identified as a pure LTB4 receptor antagonist, a new structure lead is presented to inflammation therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0163-3864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
116-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8383730-Alkaloids,
pubmed-meshheading:8383730-Animals,
pubmed-meshheading:8383730-Cells, Cultured,
pubmed-meshheading:8383730-Dioxoles,
pubmed-meshheading:8383730-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:8383730-Imidazoles,
pubmed-meshheading:8383730-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8383730-Porifera,
pubmed-meshheading:8383730-Receptors, Immunologic,
pubmed-meshheading:8383730-Receptors, Leukotriene B4,
pubmed-meshheading:8383730-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:8383730-Structure-Activity Relationship
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pubmed:year |
1993
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pubmed:articleTitle |
New leukotriene B4 receptor antagonist: leucettamine A and related imidazole alkaloids from the marine sponge Leucetta microraphis.
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pubmed:affiliation |
Research and Development, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939.
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pubmed:publicationType |
Journal Article
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