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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1993-4-12
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pubmed:abstractText |
The effect of piperacillin/tazobactam treatment on the bowel microflora was studied in 20 patients with intra-abdominal infections. The patients were treated with piperacillin 4 g and tazobactam 500 mg administered intravenously every 8 h for four to eight days. Stool specimens were collected before, during and after treatment. Six patients had measurable faecal concentrations of piperacillin (1.2-276 mg/kg) and four patients measurable concentrations of tazobactam (0.8-22.2 mg/kg) during treatment. The mean numbers of enterobacteria, enterococci, bifidobacteria, eubacteria, lactobacilli, clostridia and Gram-positive cocci decreased while the numbers of anaerobic Gram-negative cocci and bacteroides were unaffected. The aerobic and anaerobic microflora returned to normal in all patients after the treatment had stopped.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0305-7453
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31 Suppl A
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-5
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:8383656-Adult,
pubmed-meshheading:8383656-Aged,
pubmed-meshheading:8383656-Aged, 80 and over,
pubmed-meshheading:8383656-Bacteria,
pubmed-meshheading:8383656-Drug Therapy, Combination,
pubmed-meshheading:8383656-Feces,
pubmed-meshheading:8383656-Female,
pubmed-meshheading:8383656-Humans,
pubmed-meshheading:8383656-Intestines,
pubmed-meshheading:8383656-Male,
pubmed-meshheading:8383656-Middle Aged,
pubmed-meshheading:8383656-Penicillanic Acid,
pubmed-meshheading:8383656-Piperacillin,
pubmed-meshheading:8383656-beta-Lactamases
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pubmed:year |
1993
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pubmed:articleTitle |
Effect of piperacillin/tazobactam treatment on human bowel microflora.
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pubmed:affiliation |
Department of Microbiology, Huddinge University Hospital, Sweden.
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pubmed:publicationType |
Journal Article
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